ACC.17 March 17 – 19, 2017 Washington, DC, USA       The Highlights: Read the official press releases

Closing Left Atrial Appendage Reduces Stroke Risk from AFib 

In patients undergoing cardiac surgery, procedure helps prevent thromboembolism

Mar 19, 2017

For patients with atrial fibrillation (AFib), a common heart rhythm disorder, closing the area of the heart known as the left atrial appendage as an add-on procedure during cardiac surgery was associated with a 40 percent reduction in the risk ...


For Atrial Fibrillation Ablation, Newer Anticoagulant Reduces Major Bleeds 

Uninterrupted non-vitamin K antagonist oral anticoagulant is a good alternative to warfarin

Mar 19, 2017

Uninterrupted treatment with dabigatran, a non-vitamin K antagonist oral anticoagulant (NOACs), before, during and after ablation to treat atrial fibrillation significantly reduced the incidence of major bleeding events compared with uninterrup...


Genetically Guided Warfarin Dosing Lowers Risk of Some Adverse Events

Adding genotyping may be better than clinically guided dosing alone 

Mar 19, 2017

Using genetic testing to help personalize doses of warfarin therapy given to patients undergoing elective orthopedic surgery appears to lower the risk of combined adverse events compared with clinically guided dosing, according to research...


Pacemaker Program Can Reduce Dangerous Fainting Episodes

SPAIN trial meets primary endpoint of reduction in recurrent syncope

Mar 19, 2017

Patients with recurrent fainting episodes (syncope) who received a pacemaker delivering a pacing program designed to detect and stop the abnormal heart rhythms that precede syncope had a seven-fold reduction in fainting compared with patients...


Blood Test Can Detect Heart Damage after Non-Cardiac Surgery

Researchers say many deaths after surgery could potentially be prevented with monitoring, treatment

Mar 19, 2017

A blood test for a protein called high-sensitivity troponin T, which is released into the bloodstream when injury to the heart occurs, can identify patients with heart damage after non-cardiac surgery whose lives could potentially be saved ...


CT Scans Reveal Reduced Leaflet Motion After Aortic Valve Replacement

Oral anticoagulants, but not anti-platelet therapy, associated with reduced risk of clots

Mar 19, 2017

About 12 percent of patients undergoing aortic valve replacement developed non-symptomatic blood clots around the valve leaflets (known as subclinical leaflet thrombosis) that reduced the motion of the valves, according to an observational...



Heart Procedure Linked with Bleeding in the Brain, Neurological Impairment 

Microbleeds after endovascular procedures could harm thinking, memory for some patients 

Mar 19, 2017

Small leakages from blood vessels in the brain, known as microbleeds, increase with age and are associated with cognitive decline. Of 84 older patients undergoing transcatheter aortic valve replacement (TAVR), nearly a quarter developed new ...


Use of Levosimendan with Heart-Lung Machine Fails to Improve Outcomes 

Drug reduces low cardiac output syndrome, but trial does not meet primary endpoints

Mar 19, 2017

When used as a preventive measure during heart surgery, the heart failure drug levosimendan did not significantly reduce rates of death, heart attack, kidney dialysis or use of a mechanical assist device among patients at high risk for low...


New Tool For Assessing Clogged Arteries Performs Well, Reduces Discomfort

Instantaneous wave-free ratio shows benefits over fractional flow reserve in two studies

Mar 18, 2017

For patients experiencing angina (chest pain) or a heart attack, a new tool called instantaneous wave-free ratio (iFR) was equivalent to the currently-preferred tool, fractional flow reserve (FFR), in terms of incidence of major adverse events...


Outcomes for Absorb Stent Acceptable at One to Two Years, with Caveats

Risk is mitigated in subgroups with better vessel suitability, refined procedural techniques

Mar 18, 2017

Patients receiving the Absorb everolimus-eluting bioresorbable vascular scaffold (BVS), a dissolving stent to open clogged vessels around the heart, showed outcomes comparable with patients receiving the Xience drug-eluting metal stent between ...


PCI, Drugs Equally Beneficial for Treating Fully Blocked Arteries

Study shows percutaneous coronary intervention is not needed in all cases

Mar 18, 2017

In patients with a complete blockage in the heart’s arteries that persists over time, treatment with medications alone was found to be equal to percutaneous coronary intervention (PCI), a procedure to open blocked arteries, in terms of major...


Study Shows Benefits to Treating All Clogged Arteries at Once After Heart Attack

Identifying, treating secondary blockages lowers risk, helps avoid subsequent procedures

Mar 18, 2017

Patients experiencing a major heart attack often have more than one clogged artery, but under current guidelines doctors typically only clear the blockage responsible for the heart attack. Assessing and, when warranted, treating the additional...


Rivaroxaban Reduces VTE Recurrence Compared with Aspirin

No increase in bleeding complications in patients treated with blood-thinning drug

Mar 18, 2017

In patients at elevated risk for a recurrence of potentially life-threatening blood clots, a low dose of the oral blood-thinning medication rivaroxaban reduced recurrences more than three-fold compared with aspirin, with no significant increase...


Lifestyle Intervention Leads to 10-point Drop in Systolic Blood Pressure

Effect of e-Counseling is ‘similar to adding a medication,’ per researcher

Mar 18, 2017

In the first randomized, double-blinded trial of an online behavioral intervention for high blood pressure, participants in web-based lifestyle counseling reduced their systolic blood pressure (the higher number in a blood-pressure reading) by...


No Benefit of Synthetic HDL-C on Arterial Plaque

Phase 2 CARAT trial fails to meet primary endpoint

Mar 18, 2017

Injection of a novel form of synthetic high-density lipoprotein cholesterol (HDL-C), or good cholesterol, into the arteries of patients who had recently had a heart attack did not reduce the volume of fatty deposits, or plaque, in the arteries,...



No Increase in Bleeding Complications with Rivaroxaban Post-ACS 

Phase 2 study finds replacing aspirin with anticoagulant appears to be safe

Mar 18, 2017

Patients with acute coronary syndrome who were treated with the blood-thinning drug rivaroxaban in addition to an antiplatelet medication (clopidogrel or ticagrelor) experienced no increase in bleeding complications compared with patients who...

Self-Expanding TAVR As Good As Surgery in Intermediate-Risk Patients

Major trial meets non-inferiority endpoint for all-cause death and disabling stroke at two years 

Mar 17, 2017

Two-year data reveal no difference in the combined rate of stroke and death from any cause when comparing the use of self-expanding transcatheter aortic valve replacement (TAVR) with standard open-heart surgery in intermediate risk patients with...


PCSK9 Inhibition with Bococizumab Yields Mixed Results 

Drug improves cardiovascular outcomes in high-risk patients with higher LDL cholesterol at baseline; no benefit seen in patients with lower LDL 

Mar 17, 2017

In a clinical program that was terminated early, the experimental PCSK9 inhibitor bococizumab, when given on top of effective statin therapy, had widely varying effects on LDL cholesterol levels and had no benefit on cardiovascular events ...


Evolocumab Significantly Reduces Risk of Cardiovascular Events 

First outcomes trial of this PCSK9 inhibitor shows consistent benefit across patient subgroups, confirms marked drops in LDL cholesterol

Mar 17, 2017

Evolocumab, one of the new targeted PCSK9 inhibitor drugs that has been shown to dramatically lower levels of low-density lipoprotein (LDL), or "bad" cholesterol, also significantly lowers the risk of cardiovascular events in patients with...